Bioinorganic Chemistry
Investigations of biologically relevant paramagnetic iron porphyrin,
chromium, zinc, and organocobalt complexes to mimic the active sites of
important heme proteins, the glucose tolerance factor, zinc enzymes,
and vitamin B12. Synthesis of new model complexes and solution
structure analysis by spectroscopic methods, primarily by modern
multi-dimensional NMR spectroscopy to obtain new insights into the
structure-function relationships of the corresponding biomolecules.
Investigations and structural characterization of small organic
molecules, porphyrins and metalloporphyrins embedded in model membranes
aimed at synthesizing clinically useful drugs for cancer detection and
therapy. Development of the multi-dimensional NMR methodology for the
resonance assignment and structural characterization of paramagnetic
molecules to determine the scope and limits of multi-nuclear and
multi-dimensional NMR spectroscopy for the structural analysis of
paramagnetic molecules. |
